X-chromosome inactivation and escape
نویسندگان
چکیده
منابع مشابه
X Chromosome Inactivation in Opioid Addicted Women
Introduction: X chromosome inactivation (XCI) is a process during which one of the two X chromosomes in female human is silenced leading to equal gene expression with males who have only one X chromosome. Here we have investigated XCI ratio in females with opioid addiction to see whether XCI skewness in women could be a risk factor for opioid addiction. Methods: 30 adult females meeting DS...
متن کاملX-chromosome genetic association test accounting for X-inactivation, skewed X-inactivation, and escape from X-inactivation.
X-chromosome inactivation (XCI) is the process in which one of the two copies of the X-chromosome in females is randomly inactivated to achieve the dosage compensation of X-linked genes between males and females. That is, 50% of the cells have one allele inactive and the other 50% of the cells have the other allele inactive. However, studies have shown that skewed or nonrandom XCI is a biologic...
متن کاملX Chromosome: Expression and Escape
Although there are some obvious differences between the X chromosome and the autosomes—such as the X chromosome being present in only one copy in males— the two types of chromosome are remarkably similar in their cytological appearance and gene density [1]. Genomic and transcriptomic studies of Drosophila, however, have revealed two major differences in gene content between the X chromosome and...
متن کاملX chromosome-specific cDNA arrays: identification of genes that escape from X-inactivation and other applications.
Mutant alleles are frequently characterized by low expression levels. Therefore, cDNA array-based gene expression profiling may be a promising strategy for identifying gene defects underlying monogenic disorders. To study the potential of this approach, we have generated an X chromosome-specific microarray carrying 2423 cloned cDNA fragments, which represent up to 1317 different X-chromosomal g...
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ژورنال
عنوان ژورنال: Journal of Genetics
سال: 2015
ISSN: 0022-1333,0973-7731
DOI: 10.1007/s12041-015-0574-1